I'm looking for a standard high confidence VCF file to compare several dozen NA12891 samples for genotype concordance. We are testing different protocols and would like to determine which is most accurate & sensitive at calling variants. I see the resource bundle here:
ftp://ftp.broadinstitute.org/bundle/hg19/
But there are lots of options and I'm not sure what to pick. Any recommendations? Also, I've done a grep on some of these files and I can't find any NA12891
This file does however:
CEUTrio.HiSeq.WGS.b37.bestPractices.hg19.vcf.gz
Should I go with that? Use a different file? Mix and Match?