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Speeding up CatVariants to merge 1000s VCFs

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Hi,

Following the advice seen elsewhere on the forum I have performed variant calling with whole-genome resequencing data on a per-scaffold basis. Now, I need to merge 30000 or so individual VCFs and I am using CatVariants for that using the following command:

java -Xmx5G -cp GenomeAnalysisTK-3.7-0/GenomeAnalysisTK.jar org.broadinstitute.gatk.tools.CatVariants -R $ref.fasta -out $out.vcf -assumeSorted -V $allvcfs.list

Unfortunately, it appears to be very slow (about only 5000 regions processed after >24h), so I am wondering if this is the expected behavior and if there is a way to increase the speed.

Thanks

JM


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